Detalhe da pesquisa
1.
Myelin dysfunction drives amyloid-ß deposition in models of Alzheimer's disease.
Nature
; 618(7964): 349-357, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37258678
2.
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.
EMBO J
; 41(4): e109108, 2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35019161
3.
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Immunity
; 47(3): 566-581.e9, 2017 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28930663
4.
If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?
PLoS Biol
; 20(7): e3001694, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35862308
5.
Fyn-tau-amyloid: a toxic triad.
Cell
; 142(3): 356-8, 2010 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20691893
6.
Signatures of glial activity can be detected in the CSF proteome.
Proc Natl Acad Sci U S A
; 119(24): e2119804119, 2022 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35666874
7.
γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics.
EMBO J
; 39(20): e104247, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32830336
8.
Individual regional associations between Aß-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies.
Mol Psychiatry
; 28(10): 4438-4450, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37495886
9.
Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons.
EMBO Rep
; 23(6): e53890, 2022 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35438230
10.
A protein quality control pathway regulated by linear ubiquitination.
EMBO J
; 38(9)2019 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30886048
11.
Depletion and activation of microglia impact metabolic connectivity of the mouse brain.
J Neuroinflammation
; 20(1): 47, 2023 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36829182
12.
APOE and immunity: Research highlights.
Alzheimers Dement
; 19(6): 2677-2696, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36975090
13.
The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene.
J Biol Chem
; 297(4): 101120, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34450161
14.
The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease.
Mol Psychiatry
; 26(2): 614-628, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30899092
15.
Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders.
Mult Scler
; 28(4): 522-531, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34259579
16.
Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.
EMBO Rep
; 21(10): e50241, 2020 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32929860
17.
Differential interaction with TREM2 modulates microglial uptake of modified Aß species.
Glia
; 69(12): 2917-2932, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34427354
18.
Young microglia restore amyloid plaque clearance of aged microglia.
EMBO J
; 36(5): 583-603, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28007893
19.
The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.
EMBO J
; 36(13): 1837-1853, 2017 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28559417
20.
Cortical [18 F]PI-2620 Binding Differentiates Corticobasal Syndrome Subtypes.
Mov Disord
; 36(9): 2104-2115, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33951244